Studies have revealed that low-dose ketamine combined with novel memory extraction inhibits cocaine re-smoking

Barbara A., Washington State University. A study published by the Sorg team in Neuropharmacology revealed new mechanisms for ketamine in drug addiction. The study found that a single low-dose ketoxone can only effectively disrupt cocaine addiction memory and discourage resorption when combined with novel memory extraction. Researchers first assessed the impact of ketamine pretreatment on cocaine-seeking behaviour. Results showed that there were no significant differences between the four groups of experimental animals in terms of the number of active or passive levers and the amount of cocaine infusion, suggesting that the use of chloroketamine alone did not effectively reduce resortination. However, when ketamine is combined with novel memory extraction, the effect is significant: there is a marked decrease in clue-guiding resortism in experimental animals the following day, and the inhibition is faster and more lasting than the control group. By contrast, neither the use of ketazone under familiar extraction conditions nor alone can produce the same effect. Further mechanism studies have shown that ketamine interferes with the accuracy or motivation of memory by consolidating window-specific activity that weakens PV neurons during memory weights, leading to structural changes in PNN and reduced resorting behaviour. The findings provide new neurobiology mechanisms and clinical transformation thinking for treating drug addiction, emphasizing the importance of synergy between behavioural intervention and pharmacological treatment.